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20-Deoxyingenol

Synonyms:

20-deoxygenated megorbidiol; 20-deoxygenated giant halberd terpene alcohol

Cat No.:

LIA015

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Chemical Structure：

Description of 20-Deoxyingenol

20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui.

Product Information of 20-Deoxyingenol

Purity

0.9984

Molecular Weight

332.43

Formula

C₂₀H₂₈O₄

CAS Number

54706-99-9

Pack Size

10 mM * 1 mL in DMSO
5 mg/10 mg/50 mg/100 mg

Origin

Plants, Gramineae, Leptochloa chinensis (Linn.) Nees

Applications

20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro.

Shelf-Life

Powder:
-20°C, 3 years.
4°C, 2 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100 μM)-induced cell death.
20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes.

In Vivo Studies

20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice.

For research use only, not intended for any clinical use.