Exciting advances in cancer treatment have been made in the past few years. However, cancer is still the leading cause of death worldwide, and incidence rates are still increasing. This is mainly due to the frequent occurrence of inadequate response and multidrug resistance despite the abundance of therapeutic targets and treatment strategies. The combined use of histology and and modern analytical techniques has led to significant advances in the identification of new targets associated with drug resistance. Among these, targeting lysosomes in cancer has emerged as an attractive approach to overcome drug resistance. Although lysosomes have long been considered as cellular waste bags, it is now known that they play an important role in vital cellular signaling processes. Furthermore, the critical role of lysosomes in autophagy has important practical implications for the development of autophagy inhibitors as cancer therapeutic agents. Thus, targeting lysosomes has great therapeutic potential in cancer.
Fig. 1. Overview of lysosomal mechanisms contributing to chemoresistance. (Geisslinger F, et al., 2020)
Our Drug Discovery Solutions Targeting Lysosomes
The role of lysosomes in human disease involves many complex processes in disease biology, such as nutrient sensing, cell signaling, cell death, immune response, and cell metabolism. Moving from one genome to another, our scientists have worked to analyze the broad role of lysosomes in the pathophysiology of disease. In addition, we use high-throughput technologies such as transcriptomics, proteomics, and metabolomics to analyze lysosomal variants in disease using tissues of patient origin or disease model origin. Based on these effective strategies, we have successfully developed multiple biomarkers to match emerging lysosomal targeted therapies.
Here, our scientists develop disease treatment platforms targeting lysosomes with a focus on discovering the therapeutic potential of lysosomes in cancer. The reasons for lysosomes as therapeutic targets are:
(ⅰ) Can trigger apoptosis and lysosomal cell death pathways.
(ⅱ) Inhibition of cytoprotective autophagy.
(ⅲ) Lysosomes play an important role in anti-cancer drugs by isolating them in an acidic environment, thereby attenuating their effects.
CD BioSciences provides clients worldwide with available strategies for targeting lysosomes in human diseases.
- Drug Discovery Solutions for Targeting Lysosomal Acidification
- Drug Discovery Solutions for Targeting Lysosomal Cathepsins
- Drug Discovery Solutions for Targeting Lysosomal Membrane Permeability and Integrity
- Drug Discovery Solutions for Targeting Lysosomal Calcium Signaling
- Drug Discovery Solutions for Targeting Lysosomal mTOR Signaling
- Drug Discovery Solutions for Targeting Lysosomal Degradation Pathways
Advantages of Our Services
- Multiple cutting-edge technologies.
- Simple and fast experimental process to deliver results at an economical cost.
- Team with expertise and collaboration with international experts.
- Bringing hope for future lysosome-targeted adjuvants.
Our professional services for the strategies of targeting lysosomes in human disease have been well received by customers. Our highly skilled and dedicated scientific staff ensures that the most appropriate method and technology is selected for each specialized lysosomal project. If you have any special requirements about our services, please feel free to contact us. We are looking forward to working together with your attractive projects.
Reference
- Geisslinger F, et al. (2020) Targeting lysosomes in cancer as promising strategy to overcome chemoresistance—a mini review[J]. Frontiers in oncology. 10: 1156.