Autophagy is a major intracellular degradation system, and its degradative capacity comes from lysosomes. As an innovator of lysosomes, CD BioSciences is committed to creating lysosome-based technologies to help your research worry-free. Here, we provide comprehensive research services on lysosomal biology in autophagy. Our professional team will ensure that you get the most satisfactory lysosome service.
Introduction of Lysosomal Biology in Autophagy
Autophagy is an evolutionarily conserved and tightly regulated lysosomal pathway that degrades cytoplasmic material and organelles. This process is quite distinct from lysosomal degradation mediated by endocytosis of extracellular and plasma membrane proteins. Starvation and other threats to cellular homeostasis will induce autophagy to acquire nutrients by recycling non-essential substances or eliminating harmful substances. The most well-studied form of autophagy is macroautophagy, which transports cytoplasmic material to lysosomes via double-membrane autophagosomes. Other forms of autophagy, namely chaperone-mediated autophagy (CMA) and microautophagy, occur directly on the lysosome. In addition to providing a means of degradation, lysosomes are involved in autophagy regulation and can become substrates for autophagy when damaged. During autophagy, lysosomes exhibit significant changes, including increased acidification, enhanced enzymatic activity and perinuclear localization.
Fig. 1. Autophagy processes.(Yim W W Y, et al., 2020)
Our services for Lysosomal Biology in Autophagy
Although the process of autophagy is simple, it plays a wide range of physiological and pathological roles. In addition, lysosomes are important for autophagy, but research on the specific regulation of lysosomal autophagy remains relatively scarce, and the potential regulatory and functional networks of known genes controlling autophagy and lysosomal function and their roles in disease are relatively unexplored. CD BioSciences has many years of experience in lysosomal engineering, is committed to providing our global customers with expert lysosomal biology in autophagy research services. The lysosomal biology in autophagy services we provide include:
- Lysosome Biology in Macroautophagy
- Lysosome Biology in Chaperone-Mediated Autophagy
- Lysosome Biology in Microautophagy
Our scientists use integrated systems biology-based calculations to analyze the functional interactions of autophagy and lysosomal genes, as well as their synergy and flexibility in response to different physiological and environmental stimuli. In addition, we develop regulatory and functional models of genes involved in autophagy and lysosomal function. We provide customized processes for analyzing the functions and interactions that regulate the autophagy-lysosome pathway.
(1) Compilation of relevant genes from established databases.
(2) Determination of putative transcription factor binding sites by computational analysis of promoters of autophagy-lysosomal genes.
(3) Analysis of microRNA regulation of autophagy-lysosome genes.
(4) Analysis of the involvement of autophagy-lysosome genes in intracellular signaling, human diseases and neurological phenotypes in a mouse genetic model.
Available Advantages
- Experienced team with solid knowledge of lysosomal biology in autophagy.
- Advanced technologies and rich database support, such as integrated computational systems biology approaches.
- Carefully optimized experimental procedures with high efficiency and specificity.
- One-stop service allows you to seamlessly connect your upstream and downstream experiments, making your experiments more convenient and faster.
CD BioSciences continues to exploit the potential of lysosomes in an iterative process of insight and innovation. We are committed to providing professional and economical lysosome service projects to global customers. Each project will be custom designed to the client's requirements and described in a detailed project report. We look forward to working with you to discover the charm of lysosomes in our cooperation. If you are interested in our services, please feel free to contact us.
Reference
- Yim W W Y, Mizushima N. (2020) Lysosome biology in autophagy[J]. Cell discovery. 6(1): 1-12.