Because multiple pathways terminate at the lysosome, lysosomal dysfunction has a profound impact on cellular homeostasis, leading to a wide range of pathological conditions. As an innovator of lysosomes, CD BioSciences is committed to creating lysosome-based technologies to help your research worry-free. Here, we provide comprehensive services to analyze the function of lysosomes under a variety of pathological conditions. Our professional team will ensure that you get the most satisfactory lysosome service.
Introduction of Lysosome Function in Diseases
Lysosomes are organelles that play a key role in degradation, innate and adaptive immunity, and nutrient sensing. In recent years, the advent of genomics, transcriptomics, proteomics, bioinformatics and other approaches has accelerated the in-depth study of lysosomes and revealed that they function far beyond digestion. In addition, a growing body of evidence elucidates the role of lysosomes in the dynamic regulation of cellular and organismal homeostasis. Lysosomal changes and dysfunction have been associated with the development of many diseases, including atherosclerosis, neurodegenerative diseases, autoimmune diseases, pancreatitis, lysosomal storage disorders, and malignancies. The active quest to identify characteristic lysosomal changes and dysfunctions in cells affected by these diseases and the causes of these changes and dysfunctions is of great importance for the development and treatment of human diseases.
Fig. 1. Available strategies for targeting lysosomes in human disease and their corresponding drugs. (Cao M, et al., 2021)
Our services for Lysosome Function in Diseases
Lysosomal changes and dysfunctions play a critical role in disease development, but they may also provide a therapeutic window for treatment. CD BioSciences has many years of experience in lysosome engineering, is committed to providing professional services to clients worldwide to analyze lysosome function under a variety of pathological conditions. Our mission is to combine basic research with clinical discovery to help you identify characteristic changes and dysfunctions of lysosomes in cells affected by these diseases and to facilitate lysosome-targeted drug development.
Our skilled scientists have developed multiple animal disease model platforms. Not only do we analyze lysosomal changes and abnormalities in these diseases, we also develop strategies to use them to target lysosomes against diseased cells. Our services for lysosomal functional analysis in diseases include:
Quantification of Storage Material Accumulation in Tissue Sections
Being able to reliably quantify the relative extent of storage burden caused by lysosomal dysfunction is an important goal. We can achieve quantification of storage material accumulation in tissue sections to assess not only the different stages of disease progression but also therapeutic strategies.
Lysosomal Function in Aging-Related Neurodegenerative Disease
The accumulation of modified or misfolded proteins, which are prone to occur in neurodegenerative diseases, not only leads to synaptic destruction and neuronal death, but also impairs lysosomal function. We analyze lysosomal changes in a variety of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD).
Lysosomal Function in Cancer
In cancer, lysosomal changes have profound effects on the proliferation, migration and invasion of cancer cells, as well as their resistance to radiotherapy and chemotherapy. We analyze the number, localization and activity of lysosomes in cancer to facilitate the development of strategies to target lysosomes for cancer treatment.
Lysosomal Function in Lysosomal Storage Disease
Lysosomal storage diseases (LSDs) are a group of metabolic disorders caused by deficiencies in several components of lysosomal function, most often affecting lysosomal hydrolases. We provide animal models of LSDs to characterize lysosomal biology and disease mechanisms and to identify new therapeutic targets.
Lysosomal Functions in Pancreatitis
Lysosomes are involved in the pathophysiology of pancreatitis, and lysosomal dysfunction in pancreatitis is manifested by reduced maturation of histone B and histone L. We provide animal models of pancreatitis to quantify or semi-quantify autophagic activity and histonectinase activity.
Lysosomal Function in Autoimmune Disease
Lysosomes play a critical role in multiple stages of immunity, and we build animal models of autoimmune diseases to analyze lysosomal changes in cells, focusing on histone enzyme expression and activity.
Lysosomal Function in Cardiovascular Disease
Many cardiovascular diseases have been implicated in lysosomal alterations and dysfunction. The transcription factor EB (TFEB) is a major regulator of autophagy and lysosomal biogenesis genes. We analyzed the changes in TFEB factors in a mouse model of atherosclerosis.
Available Advantages
- Experienced team with solid knowledge of lysosomal biology in autophagy.
- Combining high-throughput techniques with bioinformatics methods.
- Carefully optimized experimental procedures with high efficiency and specificity.
CD BioSciences continues to exploit the potential of lysosomes in an iterative process of insight and innovation. We are committed to providing professional and economical lysosome service projects to global customers. Each project will be custom designed to the client's requirements and described in a detailed project report. We look forward to working with you to discover the charm of lysosomes in our cooperation. If you are interested in our services, please feel free to contact us.
Reference
- Cao M, et al. (2021) Targeting lysosomes in human disease: from basic research to clinical applications[J]. Signal transduction and targeted therapy. 6(1): 1-28.