Products

Welcome!
If you are interested in our products，services or solutions, please feel free to consult us through the form below. We will get back to you as soon as possible.

ONLINE INQUIRY

A 769662

Cat No.:

LIA047

Price:

Inquiry

Chemical Name:

6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Chemical Structure：

Description of A 769662

Potent AMPK activator

Product Information of A 769662

Purity

≥98% (HPLC)

Molecular Weight

360.39

Formula

C20H12N2O3S

CAS Number

844499-71-4

PubChem ID

54708532

Pack Size

10 mg/50 mg

InChI Key

CTESJDQKVOEUOY-UHFFFAOYSA-N

Smiles

OC(C1=C(N3)SC=C1C2=CC=C(C4=CC=CC=C4O)C=C2)=C(C#N)C3=O

Biological Activity

A 769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC₅₀ = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC₅₀ = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy.

Storage

Store at 4°C.

For research use only, not intended for any clinical use.