Products

Welcome!
If you are interested in our products，services or solutions, please feel free to consult us through the form below. We will get back to you as soon as possible.

ONLINE INQUIRY

ABT 263

Cat No.:

LIA049

Price:

Inquiry

Chemical Name:

4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide

Chemical Structure：

Description of ABT 263

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Product Information of ABT 263

Purity

≥98% (HPLC)

Molecular Weight

974.62

Formula

C47H55ClF3N5O6S3

CAS Number

923564-51-6

PubChem ID

24978538

Pack Size

10 mg/50 mg

InChI Key

JLYAXFNOILIKPP-KXQOOQHDSA-N

Smiles

C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

Biological Activity

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC₅₀ = 3.4 - 12 μM). in vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.

Storage

Store at -20°C.

For research use only, not intended for any clinical use.