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Amiodarone hydrochloride

Cat No.:

LIA050

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Chemical Name:

2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

Chemical Structure：

Description of Amiodarone hydrochloride

Broad spectrum ion channel blocker; antiarrhythmic

Product Information of Amiodarone hydrochloride

Purity

≥99% (HPLC)

Molecular Weight

681.77

Formula

C25H29I2NO3.HCl

CAS Number

19774-82-4

PubChem ID

29770

Pack Size

50 mg

InChI Key

ITPDYQOUSLNIHG-UHFFFAOYSA-N

Smiles

CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

Biological Activity

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca²⁺² influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Storage

Store at 4°C.

For research use only, not intended for any clinical use.