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Apilimod dimesylate

Cat No.:

LIA020

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Chemical Name:

4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

Chemical Structure：

Description of Apilimod dimesylate

Potent and selective PIKfyve inhibitor

Product Information of Apilimod dimesylate

Purity

≥98% (HPLC)

Molecular Weight

610.7

Formula

C23H26N6O2.2CH3SO3H

CAS Number

870087-36-8

PubChem ID

91885471

Pack Size

5 mg/25 mg

InChI Key

GAJWNIKZLYZYSY-OKUPSQOASA-N

Smiles

C[S](O)(=O)=O.C[S](O)(=O)=O.CC1=CC=CC(\C=N\NC2=CC(=NC(OCCC3=CC=CC=N3)=N2)N2CCOCC2)=C1

Biological Activity

Apilimod dimesylate is a potent and selective PIKfyve inhibitor (IC₅₀ = 14 nM). Exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. Reduces number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. Also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma compared with normal cells. Inhibits production of IL-12 and IL-23. Anti-inflammatory. Water-soluble.

Storage

Store at -20°C.

For research use only, not intended for any clinical use.