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Bafilomycin A1

Synonyms:

BafA1

Cat No.:

LIA004

Price:

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Chemical Structure：

Description of Bafilomycin A1

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg.

Product Information of Bafilomycin A1

Purity

0.9897

Molecular Weight

622.83

Formula

C₃₅H₅₈O₉

CAS Number

88899-55-2

Pack Size

100 μg/500 μg/1 mg/ 5 mg/10 mg/ 50 mg

Target

V-ATPase

Applications

Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

Shelf-Life

Powder:
-20°C, 3 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

Bafilomycin A1 ((-)-Bafilomycin A1) disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion.

In Vivo Studies

Chronic treatment with low-dose Bafilomycin A1 (0.1 mg/kg) slightly inhibits the tumor volume, but the final tumor volume does not differ significantly from the control. However, chronic treatment with high dose Bafilomycin A1 (1 mg/kg) inhibits the tumor growth significantly, compared with controls, after 21 days.

For research use only, not intended for any clinical use.