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Brefeldin A

Cat No.:

LIA051

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Chemical Name:

1,6,7,8,9,11aβ,12,13,14,14aα-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent[f]oxacyclotridecin-4-one

Chemical Structure：

Description of Brefeldin A

Disrupts protein translocation to Golgi

Product Information of Brefeldin A

Purity

≥98% (HPLC)

Molecular Weight

280.36

Formula

C16H24O4

CAS Number

20350-15-6

PubChem ID

6436187

Pack Size

5 mg

InChI Key

KQNZDYYTLMIZCT-SZXCEISTSA-N

Smiles

O[C@@H]([C@H]1[C@H](/C=C/CCC[C@H](C)O2)C[C@H](O)C1)/C=C/C2=O

Biological Activity

Brefeldin A is a reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.

Storage

Store at -20°C.

For research use only, not intended for any clinical use.