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CA-5f

Cat No.:

LIA018

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Chemical Structure：

Product Information of CA-5f

Purity

0.994

Molecular Weight

388.46

Formula

C₂₄H₂₄N₂O₃

CAS Number

1370032-19-1

Pack Size

10 mM * 1 mL in DMSO
5 mg/10 mg/50 mg/100 mg/200 mg/500 mg

Target

Macroautophagy, autophagy

Applications

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

Shelf-Life

Powder:
-20°C, 3 years.
4°C, 2 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

CA-5f (0-40 μM, 6 hour) concentration- and time-dependently elevates the level of LC3B-II (a marker to monitor autophagy) and SQSTM1 protein both in A549 cells and HUVECs.
CA-5f (20 μM, 6 hours) inhibits the degradation of autophagosomes when treated alone or in combination Bafilomycin A1 (100 nM) or Chloroquine (30 μM) in A549 cells and HUVECs.

In Vivo Studies

CA-5f (40 mg/kg, i.p., every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, i.p.) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.

For research use only, not intended for any clinical use.