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Dorsomorphin dihydrochloride

Synonyms:

Compound C, BML-275

Cat No.:

LIA055

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Chemical Name:

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride

Chemical Structure：

Description of Dorsomorphin dihydrochloride

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Product Information of Dorsomorphin dihydrochloride

Purity

≥98% (HPLC)

Molecular Weight

472.41

Formula

C24H25N5O.2HCl

CAS Number

1219168-18-9

PubChem ID

49761481

Pack Size

10 mg/50 mg

InChI Key

RJDVIJJQKMGPMV-UHFFFAOYSA-N

Smiles

C(C=N2)(C4=CC=C(OCCN5CCCCC5)C=C4)=CN1C2=C(C3=CC=NC=C3)C=N1.Cl.Cl

Biological Activity

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Storage

Store at room temperature.

For research use only, not intended for any clinical use.