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EB 1089

Synonyms:

Seocalcitol

Cat No.:

LIA056

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Chemical Name:

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

Chemical Structure：

Description of EB 1089

Vitamin D receptor (VDR) agonist

Product Information of EB 1089

Purity

≥98% (HPLC)

Molecular Weight

454.68

Formula

C30H46O3

CAS Number

134404-52-7

PubChem ID

5288149

Pack Size

1 mg

InChI Key

LVLLALCJVJNGQQ-SEODYNFXSA-N

Smiles

C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/C=C/C(CC)(O)CC)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

Biological Activity

EB 1089 is a vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Storage

Store at -20°C.

For research use only, not intended for any clinical use.