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EN6

Cat No.:

LIA057

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Chemical Name:

N-[4-Fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide

Chemical Structure：

Description of EN6

H⁺ ATPase activator; activates autophagy; inactivates mTORC1 signaling

Product Information of EN6

Purity

≥98% (HPLC)

Molecular Weight

368.34

Formula

C19H14F2N4O2

CAS Number

1808714-73-9

PubChem ID

99640033

Pack Size

10 mg/50 mg

InChI Key

SUSXQEYPNDORDQ-UHFFFAOYSA-N

Smiles

O=C(C=C)NC1=CC(=CC=C1F)NC(=O)C=2C=NN(C2)C=3C=CC=CC3F

Biological Activity

EN6 is an activator of lysosomal vacuolar H⁺ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.

Storage

Store at -20°C.

For research use only, not intended for any clinical use.