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Everolimus

Synonyms:

RAD001

Cat No.:

LIA058

Price:

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Chemical Name:

42-O-(2-Hydroxyethyl)rapamycin

Chemical Structure：

Description of Everolimus

mTOR inhibitor; Immunosuppressant

Product Information of Everolimus

Purity

≥98% (HPLC)

Molecular Weight

958.22

Formula

C53H83NO14

CAS Number

159351-69-6

PubChem ID

100926147

Pack Size

10 mg

InChI Key

HKVAMNSJSFKALM-GKUWKFKPSA-N

Smiles

[H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

Biological Activity

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Storage

Store at -20°C.

For research use only, not intended for any clinical use.