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FK 866 hydrochloride

Cat No.:

LIA059

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Chemical Name:

2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride

Chemical Structure：

Description of FK 866 hydrochloride

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

Product Information of FK 866 hydrochloride

Purity

≥98% (HPLC)

Molecular Weight

427.97

Formula

C24H29N3O2.HCl

PubChem ID

78243733

Pack Size

10 mg

InChI Key

MULSIBUGDPOSHV-CALJPSDSSA-N

Smiles

O=C(C2=CC=CC=C2)N1CCC(CCCCNC(/C=C/C3=CN=CC=C3)=O)CC1.Cl

Biological Activity

FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC₅₀ ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

Storage

Store at -20°C.

For research use only, not intended for any clinical use.