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GF 109203X

Synonyms:

Gö 6850, Bisindolylmaleimide I

Cat No.:

LIA061

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Chemical Name:

2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide

Chemical Structure：

Description of GF 109203X

Protein kinase C inhibitor

Product Information of GF 109203X

Purity

≥98% (HPLC)

Molecular Weight

412.49

Formula

C25H24N4O2

CAS Number

133052-90-1

PubChem ID

2396

Pack Size

1 mg/10 mg

InChI Key

QMGUOJYZJKLOLH-UHFFFAOYSA-N

Smiles

CN(C)CCCN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CNC2=CC=CC=C12

Biological Activity

GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC₅₀ values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC₅₀ values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Kⁱ = 29.5 nM). Anti-inflammatory in vivo.

Storage

Store at room temperature.

For research use only, not intended for any clinical use.