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cis-Ned 19

Cat No.:

LSK009

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Chemical Name:

(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Chemical Structure：

Description of cis-Ned 19

Fluorescently labels NAADP receptors in intact cells; inhibits Ca²⁺ release

Product Information of cis-Ned 19

Purity

≥97% (HPLC)

Molecular Weight

514.59

Formula

C30H31FN4O3

CAS Number

1137264-00-6

PubChem ID

1427626

Pack Size

1 mg

InChI Key

FUHCEERDBRGPQZ-LSYYVWMOSA-N

Smiles

FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H]([C@@](O)=O)N3)=CC=C2OC

Biological Activity

cis-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca²⁺ release (IC₅₀ = 800 nM) and [³²P]NAADP binding (IC₅₀ = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Storage

Store at -20°C.

For research use only, not intended for any clinical use.

cis-Ned 19

Description of cis-Ned 19

Product Information of cis-Ned 19