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IITZ-01

Cat No.:

LIA014

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Chemical Structure：

Product Information of IITZ-01

Purity

0.9905

Molecular Weight

482.51

Formula

C₂₆H₂₃FN₈O

CAS Number

1807988-47-1

Pack Size

Free Sample (0.1-0.5 mg)
10 mM * 1 mL in DMSO
5 mg/10 mg/50 mg/100 mg/200 mg/500 mg

IC₅₀

2.62 μM

Target

PI3Kγ

Applications

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity.

Shelf-Life

Powder:
-20°C, 3 years.
4°C, 2 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.

In Vivo Studies

IITZ-01 (45 mg/kg, i.p. every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.

For research use only, not intended for any clinical use.