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trans-Ned 19

Cat No.:

LSK010

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Chemical Name:

(1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Chemical Structure：

Description of trans-Ned 19

Fluorescently labels NAADP receptors in intact cells; inhibits Ca²⁺ release

Product Information of trans-Ned 19

Purity

≥98% (HPLC)

Molecular Weight

514.59

Formula

C30H31FN4O3

CAS Number

1354235-96-3

PubChem ID

1427628

Pack Size

1 mg

InChI Key

FUHCEERDBRGPQZ-LBNVMWSVSA-N

Smiles

FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H](C(O)=O)N3)=CC=C2OC

Biological Activity

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca²⁺ release (IC₅₀ = 6 nM); also inhibits [³²P]NAADP binding (IC₅₀ = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).

Storage

Store at -20°C.

For research use only, not intended for any clinical use.