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Lalistat 1

Cat No.:

LIA017

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Chemical Structure：

Description of Lalistat 1

Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC₅₀ of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.).

Product Information of Lalistat 1

Purity

0.9871

Molecular Weight

298.36

Formula

C₁₂H₁₈N₄O₃S

CAS Number

501104-16-1

Pack Size

5 mg/10 mg/50 mg

IC₅₀

68 nM

Target

Human LAL

Applications

Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease.

Storage

Store at -20°C, sealed storage, away from moisture.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

Lalistat 1 (0-100 μM) shows activity against different non-typeable H. influenzae (NTHi) IgAP variants from clinical isolates in Elisa assay. It shows a dose-dependent inhibition of IgA1P B1 and B2, but at higher inhibitor concentrations, consistent with the higher expression levels of these variants. Nearly complete inhibition of IgA1P B1 and B2 is observed at 50 μM, with complete inhibition at 100 μM.

For research use only, not intended for any clinical use.