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Leupeptin hemisulfate

Cat No.:

LIA012

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Chemical Structure：

Product Information of Leupeptin hemisulfate

Purity

0.98

Molecular Weight

475.59

Formula

C₂₀H₃₈N₆O₄.1/2H₂SO₄

CAS Number

103476-89-7

Pack Size

Free Sample (0.1-0.5 mg)
10 mM * 1 mL in Water
5 mg/10 mg/50 mg/100 mg/200 mg

Target

Cathepsin

Applications

Leupeptin hemisulfate is a membrane-permeable thiol protease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion.

Storage

Store at -20°C, sealed storage, away from moisture

Shelf-Life

In solvent:
-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vivo Studies

Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction.

Sequence Shortening

Ac-LLR-CHO

For research use only, not intended for any clinical use.