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MHY1485

Cat No.:

LIA013

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Chemical Structure：

Description of MHY1485

MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

Product Information of MHY1485

Purity

0.9974

Molecular Weight

387.39

Formula

C₁₇H₂₁N₇O₄

CAS Number

326914-06-1

Pack Size

Free Sample (0.1-0.5 mg)
10 mM * 1 mL in DMSO
5 mg/10 mg/50 mg/100 mg/200 mg/500 mg/1 g

Target

mTORC1, mTORC2, Autophagy

Applications

MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR.

Shelf-Life

Powder:
-20°C, 3 years.
4°C, 2 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.

Shipping Conditions

Room temperature in continental US, may vary elsewhere.

In Vitro Studies

MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.

In Vivo Studies

MHY1485 (intraperitoneal injection; 10 mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group.

For research use only, not intended for any clinical use.