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Mouse Chitinase 3-like 1 Quantikine ELISA Kit

Cat No.:

LBR003

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Description of Mouse Chitinase 3-like 1 Quantikine ELISA Kit

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

Product Information of Mouse Chitinase 3-like 1 Quantikine ELISA Kit

Pack Size

96-well strip plate

Sampe Type

Cell Culture Supernates (50 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Urine (50 uL)

Applications

The Quantikine Mouse CHI3L1 immunoassay is a 4.5 hour solid-phase ELISA designed to measure CHI3L1 in cell culture supernates, mouse serum, and plasma. It contains NS0-expressed recombinant mouse CHI3L1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse CHI3L1.

Assay Type

Solid Phase Sandwich ELISA

Assay Length

4.5 hours

Assay Range

62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Specificity

Natural and recombinant mouse CHI3L1

Sensitivity

16 pg/mL

Cross-Reactivity

< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.

Storage

Store the unopened product at 2 - 8°C. Do not use past expiration date.

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

For research use only, not intended for any clinical use.