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SKI II

Cat No.:
LIA016
Price:
Chemical Structure:

Description of SKI II

SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity.

Product Information of SKI II

Purity
0.9988
Molecular Weight
302.78
Formula
C15H11ClN2OS
CAS Number
312636-16-1
Pack Size
Free Sample (0.1-0.5 mg)
10 mM * 1 mL in DMSO
5 mg/10 mg/50 mg/100 mg/200 mg/500 mg/1 g
IC50
78/45 μM
Target
SK1/2
Shelf-Life
Powder:
-20°C, 3 years.
4°C, 2 years.

In solvent:
-80°C, 6 months.
-20°C, 1 month.
Shipping Conditions
Room temperature in continental US, may vary elsewhere.
In Vitro Studies
SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II promotes the degradation of β-catenin by enhancing Wnt5A.
SKI II (1.25 μM, 48 h) in combination with DDP has a clear synergistic effect in human gastric carcinoma SGC7901/DDP cell line.
In Vivo Studies
Chronic SKI II (50.0 mg/kg, 3-weekly i.p. for 16 weeks) administration leads to permanent reduction of S1P concentrations in plasma in mice.
SKI II (50.0 mg/kg, IP; 100 mg/kg, PO) treatment reduces tumor growth in mice bearing solid tumor model.

For research use only, not intended for any clinical use.