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Spautin 1

Cat No.:

LIA042

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Chemical Name:

6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine

Chemical Structure：

Description of Spautin 1

USP10 and USP13 inhibitor; inhibits autophagy

Product Information of Spautin 1

Purity

≥98% (HPLC)

Molecular Weight

271.26

Formula

C15H11F2N3

CAS Number

1262888-28-7

PubChem ID

51037431

Pack Size

10 mg/50 mg

InChI Key

AWIVHRPYFSSVOG-UHFFFAOYSA-N

Smiles

FC1=CC=C(N=CN=C2NCC3=CC=C(F)C=C3)C2=C1

Biological Activity

Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC₅₀ values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Storage

Store at 4°C.

For research use only, not intended for any clinical use.