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Wortmannin

Synonyms:

SL-2052

Cat No.:

LIA045

Price:

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Chemical Name:

(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione

Chemical Structure：

Description of Wortmannin

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Product Information of Wortmannin

Molecular Weight

428.44

Formula

C23H24O8

CAS Number

19545-26-7

PubChem ID

3003565

Pack Size

1 mg/5 mg

InChI Key

QDLHCMPXEPAAMD-ZGSWIPFCSA-N

Smiles

O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O

Biological Activity

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).

Storage

Store at -20°C.

For research use only, not intended for any clinical use.