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Xanthohumol

Cat No.:

LIA046

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Chemical Name:

(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Chemical Structure：

Description of Xanthohumol

p97 ATPase (VCP) inhibitor

Product Information of Xanthohumol

Purity

≥98% (HPLC)

Molecular Weight

354.4

Formula

C21H22O5

CAS Number

6754-58-1

PubChem ID

639665

Pack Size

10 mg

InChI Key

ORXQGKIUCDPEAJ-YRNVUSSQSA-N

Smiles

OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

Biological Activity

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC₅₀ = 50.3 μM).

Storage

Store at 4°C.

For research use only, not intended for any clinical use.