Since its discovery more than 70 years ago, the lysosome has been known for its important role in the turnover of macromolecules. Methodological advances have advanced our knowledge of this multifaceted organelle biology. CD BioSciences' expertise in lysosomes provides strong support for lysosomal morphology monitoring services. Our advanced imaging technology platform will bring you efficient and economical services, ensuring your 100% satisfaction.
Lysosome Morphology
Lysosome is an abundant organelle. In addition to serving as specialized degradative organelles, lysosomes play important roles in several other cellular functions, such as nutrient sensing, intracellular signaling, and metabolism. The normal function of lysosomes depends on their number and location in the cell, both of which are dynamic regulatory events related to energy state. Defects in import, transport, and perturbation of cellular homeostasis have all been found to affect the structure of the lysosomal system. Thus, lysosomal morphology can serve as an indicator of endocytic health. Meanwhile, changes in lysosomal structure are seen in many lysosomal storage diseases. At present, scientists have successfully used a variety of methods to analyze lysosome morphology, positioning, movement and function, which is of great significance for identifying lysosomes and assessing their characteristics and functions.
Fig. 1. Lysosomes play a crucial role in intracellular transport. (Tang T, et al., 2020)
Our Lysosome Morphology Analysis Services
CD BioSciences has developed detailed protocols for analyzing lysosomal morphology. We are committed to serving our global customers with advanced methods for monitoring lysosome morphology, utilizing its acidic pH, functionally coupled to endocytic pathways, and expressing abundant tagged proteins. We synthesize the rationale behind these methods, methodological strategies and their advantages and limitations to select an effective and cost-effective service for your project. Furthermore, we provide optimal strategies for identifying lysosomes and assessing their characteristics and functions, realizing what to extract from the results and how to perform them correctly to produce accurate and reproducible results.
Our goal is to stimulate an increase in the quantity and quality of lysosomal research and further breakthrough discoveries about organelles that will continue to amaze and excite cell biologists. Here, we provide services for analyzing lysosome morphology as follows:
Advantages of Our Services
- The resolution of imaging technology in time and space is further improved to provide technical support.
- Enables visualization of the dynamics of this organelle in living cells.
- Better understanding of the heterogeneity of different lysosomal populations and their characteristics.
- Providing theoretical support for the role of lysosomes in cell physiology.
- A deeper understanding of lysosomal biology could lead to new therapeutic strategies for lysosomal diseases.
Our services are widely used to monitor lysosome morphology in fixed and living cells. Our highly skilled and dedicated scientific staff ensures that the most appropriate method and technology is selected for each specialized lysosomal project. If you have any special requirements about our services, please feel free to contact us. We are looking forward to working together with your attractive projects.
References
- Tang T, Yang Z, Wang D, et al. (2020) The role of lysosomes in cancer development and progression[J]. Cell & bioscience. 10(1): 1-18.
- Barral D C, Staiano L, Guimas Almeida C, et al. (2022) Current methods to analyze lysosome morphology, positioning, motility and function[J]. Traffic. 23(5): 238-269.